Growing broilers without antibiotics, Novyrate® C and Lumance® — an alternative to antibiotics

It is known that antibiotics are introduced into rations and water so that the birds and animals quickly gain weight or consume less food. However, the use of antibacterial preparations leads to the development of resistance. Therefore, antibiotics should be applied only when necessary (as per indications).

Resistant bacteria are one of the serious threats to human health, because potential mortality in diseases caused by strains of resistant bacteria increases if the effectiveness of the drugs used is reduced.

To minimize the use of antibiotics and increase the chances of success at economically acceptable costs, all aspects of livestock farming are considered integrally. It is generally believed that fully vegetable rations are most effective, but to reduce the negative impact of non-starch polysaccharides on the body, it is desirable to add enzymes to the diet. It is important that the diet is balanced by content of such nutrients as proteins, synthetic amino acids, etc. Besides, it should be stable, because in this case the risk of violation of the feeding regime is reduced. It is necessary to control the food particles size and be very careful when including food production waste. Acidification of water during the first week of chickens' life is one of the main factors for successful start in poultry. Creation of comfortable welfare and an optimum microclimate in premises (ventilation, temperature, illumination, etc.) facilitate preservation of livestock health. Besides, it is advisable to reduce the broilers stocking density and observe the appropriate time interval between the subsequent stockings (organize work based on the principle "entire pace is empty - entire space is occupied"?).

To get healthy birds without the use of antibiotics, it is necessary to monitor the litter condition and also competently vaccinate against coccidiosis. Broilers production programs without antibiotics are different, and the success of their implementation is also different. It is important to realize that one poultry complex varies from the other, which means that an individual approach is required to each of them. After analyzing the survey of livestock experts, feeding specialists, veterinarians, and poultry farms managers from different countries, it was concluded that one of the most common problems on farms is outbreaks of enteritis, both necrotic and bacterial. A farm suffers from economic losses caused by this disease already at an early stage of broiler farming. The right approach is to prevent problems. Fodder additives or products added to water are useful and effective means of prevention. Lumance additive (Lumance®) is a mixture of balanced, synergistically acting ingredients. It has prolonged effect and contributes to improving the birds' intestine health. The composition includes oil, propionic, sorbic, lauric acids, medium chain fatty acids, butyrates, essential oils, anti-inflammatory compounds and polyphenols, which, when entering the intestine, have a powerful antibacterial effect, and also perform a barrier function, neutralize reactive oxygen species (ROS), and help reduce the inflammatory mediators formation. Studies were conducted in the European Union to determine the effectiveness of Lumance® as a growth stimulator. The experiment was carried out in a controlled farm environment with low extent of bacterial load. For the experiment, 960 day-old male chickens of the "Ross 308" cross were selected and divided into four groups. All the chickens were from the same parent nest and were divided by sex in the incubator. The bird in the reference group (T1) were fed without any additives. Young birds from experimental (T2-T4) were fed with feed additives in various doses.

Experiment was performed as per the following scheme:

• reference group Т1 — basic diet with no additives

• experimental group T2 — basic diet + polyphenol-based supplement ;

• experimental group T3 — basic diet + single-component short-chain fatty acids;

• experimental group T4 — basic diet + Lumance® .

During the initial period (up to 14 days), during the growing (15th to the 28th day), and during the final period (29th to 35th day) three-phase feeding with a mash made of corn, wheat and soybean was used. At various stages, the dosage of additives was 1,000, 500 and 250 g, respectively, per 1 ton of feed. Basic diets did not contain any components with antibacterial action, except coccidiostats. The experiment results are shown in the Table 1.

Table 1

Zootechnic indicators for the growing period (1-35 days)









Live weight of broiler at the age of 35 days, kg









Feed consumption, g/head per day









Live weight gain, g/head per day









Feed conversion rate









Mortaility, %






In the course of the experiment it was found that during the growth period male chickens of all the groups showed a good growth rate with a lower feed intake level. The highest daily average live weight gain and the best feed conversion rate (р < 0.05) were in the T4 group, where Lumance®was introduced into the chickens' diet. The broilers of the experimental groups T2 and T3 had daily live weight increments of slightly lower than those of the analogues consuming Lumance®. The mortality rate was within normal limits. On the first (up to 14 days) and the second (15th to 28th day) stages of growing, male chickens fed with a diet with addition of Lumance®), had productivity indicators (daily average live weight gain and feed conversion rate) better than the chickens, getting other supplements. This indicates an excellent start and successful support of the body. Thus, the use of Lumance® in a controlled environment of the research station contributed to the improvement of the grown poultry zootechnic parameters, leading to the conclusion that the additive has a positive effect on the chickens' growth. A replicated experiment was held at the Zoology Faculty of of the University of Oklahoma (USA). Lumance® additive was used as a substitute for one of the preparations, a bacteriostatically acting antibiotic and a growth stimulant. For the experiment, 350 day-old male chickens of the "Cobb 308" cross were selected and divided into five groups. Ten nests were formed with seven heads in each. Young chickens were kept under normal conditions. Before the beginning of the studies, the chickens were weighed cell-by-cell and for 21 days were fed with a basic diet containing no antibiotics. Novyrate® C in a dose of 1 g/kg, Lumance®) (1 g/kg), powdered sodium butyrate 2 g/kg (unprotected) and antibiotic (20 mg/kg) were added to the feed of experimental group chickens. Chickens were weighed weekly, and feed intake was recorded. Growth indicators (average live weight, average daily increments, feed intake and feed conversion ratio) were determined during the first seven days, during days 7-14, during days 14-21 and for the entire period (21 days). Birds that got diets with added Novyrate® C, Lumance® products and antibiotc preparation featured improvement of growth indicators three weeks after the moment of additives inclusion to the feed (Table 2).

Table 2

Influence of additives on the growth of male chickens



Standard error




Feed additives




Unprotected butyrate

Average live weight, g

Beginning of the experiment








21th day







< 0.001

Average daily gains, g

day 0–21







< 0.001

Average daily feed intake, g

day 0–21








Feed conversion rate

day 0–21







< 0.0001


Comment. The data represent mean values of ten repetitions for 4-7 chickens per cage. The average values in the same row without common upper indexes differ significantly (p <0.05).

In contrast to the birds in the control group, the live weight and average daily gain increased significantly for the male chickens fed a diet supplemented with Novyrate® C, Lumance® and antibiotics. With increased feed conversion (p < 0.05) its consumption remained at the same level. In general, the effect of adding Novyrate® C and Lumance® is comparable with the effect of antibiotic and even higher. Chickens fed with a diet with Novyrate® C had higher live weight and average daily growth during the first week of growing (р < 0.05). In male chickens getting feed with the inclusion of Lumance® and antibiotic, live weight and average daily gain increased only on the second week. At the end of the third week, the live weight of broilers consuming mixed fodder with Novyrate® C, Lumance® and antibiotic increased significantly comparing to similar indicators of the reference group (by 25.5, 29.7 and 25.6% respectively). As there were no significant differences in the average daily intake of feed by poultry in experimental groups, the feed conversion coefficient in them deceased significantly by 28.9, 25.4 and 18.3%, respectively. Differences began to appear from the second week. In general, the experimental results indicated that the addition of Novyrate® C (2 g/kg) and Lumance® (1 g/kg) had a stimulating effect on the growth of young chickens, while the effectiveness of the additives was the same as that of the commonly used feed antibiotic. It should be noted that adding to the feed unprotected sodium butyrate in a dose of 1 g/kg showed a numerical but statistically insignificant increase (р > 0.05) in the live weight of males at the end of the second and third weeks of growing. Since there was a tendency of feed intake to decrease (р > 0.05) in the group where young chickens were getting a diet with the addition of unprotected butyrate, the feed conversion has significantly improved (р < 0.05). The indicators were comparable to those of broilers in other groups. Birds consuming feed with sodium butyrate in unprotected form had their live weight and average daily gain decreased, while male chickens fed with the diet with Novyrate® C or Lumance® - both products contain sodium butyrate with a predetermined release rate - had these indicators increased. Therefore, it can be concluded that microcapsulation or etherification of butyrate increase feed intake and increase growth rates. In general, Novyrate® C and Lumance® are superior in their properties comparing to unprotected sodium butyrate, but as stimulators of broilers growth and productivity are identical to the feed antibiotic. Specialists recommend to include Novyrate® C and Lumance® preparations to the diet, as they serve as an effective alternative to bacteriostatically acting agents.

Abstract: Novyrate® C Lumance® preparations are superior in their properties comparing to unprotected sodium butyrate, and as stimulators of broilers growth and productivity are identical to the feed antibiotic. Specialists recommend to include Novyrate® C and Lumance® to the diet, as they serve as an effective alternative to bacteriostatically acting agents. Keywords: poultry industry, broilers, male chickens, poultry, chicken, antibiotics, feed, feeding, diet, resistance, strain, bacterium, coccidiosis, coccidiostatics, non-starch polysaccharides, livestock, stocking density, vaccination, enteritis, medium chain fatty acids, protected and unprotected sodium butyrate, essential oils, growth stimulant, parent flock, live weight, feed conversion, productivity, average daily gain, mortality, Ross 308 and Cobb cross, Novyrate® C, Lumance® , bacteriostats.


Written by: Stefan BAUENS, Technical Director





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