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19.07.17

Lumance is more effective than antibiotics

Intestinal health is one of the most important and complex aspects associated with animals feeding. This concept includes functionality and integrity of the gastrointestinal tract, the condition of microflora, its symbiosis with the host, which also plays a very important role.

Intestinal health of pigs is a factor determining the level of a farm profitability. Colonization of the gastrointestinal tract by pathogenic bacteria leads to clinical and subclinical diseases.

It results, as a rule, in feed consumption decreasing, mass gain decreasing, so animals become sluggish, their social interaction weakens.

The gastrointestinal tract surface area is 300 times larger than the skin area. The intestine should provide the same level of protection from pathogens as the skin, and have high permeability to absorb nutrients at the same time. The intestinal mucosa is covered by a single layer of enterocytes, and their main function is to create a reliable barrier against bacteria, toxins and other pathogens from the intestine contents to the sterile body environment.

There are several stress factors that affect protective functions of the mucosa and lead to the increased intestinal permeability syndrome. With its development, large molecules, such as toxins and aggressive radicals, can destroy the cellular barrier of the intestine, which stimulates the production of active oxygen forms and causes the immune system stress. The cytokines synthesis increases automatically, and allergic and inflammatory reactions occur. To neutralize them, a considerable amount of energy and nutrients is needed, which means that the animal muscle tissue buildup slows down, and the feed intake per unit of growth increases. Although the mechanism of antibiotics -growth stimulants (AGSs) action has not yet been fully studied, there is a reason to believe that in addition to microflora regulation, AGSs also play an important role in reducing the level of pro-inflammatory cytokines release, which significantly saves energy and increases body weight gain.

The intestinal microbiome (the habitat of many microscopic organisms originating from more than 500 different species) provides the intestinal wall with energy and nutrients, preventing from harmful bacteria colonization and regulating local immunity.

When in 1950 the use of AGSs became popular, they were considered a panacea, a universal tool to improve intestinal health, weight gain and economic efficiency of the farm. With the expansion of the fodder antibiotics use (of which 60-80% are necessary for treatment of digestive disorders) since 1990, both scientists and the public began to discuss the issue of increasing bacterial resistance to antibiotics and their possible transfer to humans under appropriate conditions. This led to complete ban on AGSs since January 2006 in Europe, and to a significant reduction of feed antibiotics use in many countries of the European Union. The goal is to reduce this figure by 50-70% in the next 2-5 years in different countries. Management and feeding, of course, play a role in this task.

Everyone knows how complicated the digestive system is. Most scientists and veterinarians agree that the use of single-component drugs other than antibiotics limits control over the general condition of the gastrointestinal tract.

Innovad (Belgium) offers a conceptual and synergistic approach that allows ensuring health of the animals’ intestines. Three years ago, the company developed a new product, Lumance, which has a special structure and contains a new-generation butyrate. Due to slow release and application of substances protection technology, medium chain fatty acids and other organic acids, essential oils, anti-inflammatory compounds and polyphenols will be reliably delivered to the intestine in active form. They will be able to show a powerful and effective antibacterial action, providing a good barrier function of the intestinal mucosa and normalizing the level of proinflammatory cytokines secretion.

Studies conducted in Italy compared results in three groups. The first one (positive control) received amoxicillin (500 ppm), celestine (120 ppm) and zinc oxide (3000 ppm), the second one (negative control) received amoxicillin (500 ppm), the third group - amoxicillin (500 ppm) and 1 kilo of new-generation butyrate. In the third group, the treatment was more cost-effective than in the first one. The second group visually demonstrated the problems on the farm - low weight gain, active individual treatment with medications and weak fecal scoring. The new-generation butyrate helped compensate the growth losses in full, raising it to the values of the first group. Individual antibiotic use decreased significantly after enriching the diet with Lumance, and fecal scoring data were improved in comparison with the results of the control group.

The table (check at the bottom of the text) shows the results obtained at the academic experimental farm in Lithuania in 2014 (Lithuanian University of Health Sciences, Veterinary Academy), where 400 piglets (pietren x large white) were divided in two groups. Treatment efficacy in the control group and in the experimental group, where the animals received butyrate (1.5 kg/ton) at the age of 30 to 60 days was compared. The data support Lumance: due to its use, the weight gain was increased while the number of observed gastrointestinal disorders decreased simultaneously.

Reducing of fodder antibiotics use for healthy animals and animals giving good growth is a difficult and decisive step. For a farm to be able to compete with the farms implementing a traditional approach to the antibiotics use, management and feeding should go hand in hand. The use of Lumance, which has a synergistic effect, makes it possible to obtain better results than administration of antibiotics. The product has become a real alternative to these drugs and one-component feed additives that increase weight gain, even in situations where the animals have no gastrointestinal problems.

 

Weight gain increase and reduced incidence of gastrointestinal disorders with the use of Lumance

 

Group

Mass, kilos

ASG use, g

at baseline

at the end of the study

Control

10,4

18,4

266

Experimental

10,5

19,2

290

 


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